
Unlock superior cellular energy with Thorne Riboflavin 5-Phosphate R5P, the bioactive form of Vitamin B2 designed for optimal absorption and enzymatic function. Unlike standard Riboflavin, which the body must convert, this tissue-ready formula delivers immediate support for your metabolism and nervous system.
Best Vitamin B2 for MTHFR & Methylation Support
Many individuals have a genetic difficulty converting standard vitamins into their active forms. R5P is the Active B2 cofactor required for the proper function of the MTHFR enzyme.
- Folate Activation: Without adequate active Riboflavin, the body struggles to process Folate (B9), impacting the entire methylation cycle.
- Vitamin Synergy: This formula is essential for converting Vitamin B6 into its active form (P5P), creating a comprehensive B-vitamin support system.
Mitochondrial Energy & Head Comfort
Research suggests that Riboflavin for migraines protocols may support mitochondrial efficiency in the brain. By enhancing the production of cellular energy (ATP), Riboflavin 5′-Phosphate helps maintain healthy neurological function.
This Mitochondrial energy supplement is widely utilized by practitioners to support healthy mucous membranes and eye structure while combating cellular fatigue.
Pure Ingredients, Clinical Standards
Thorne Research is renowned for its “No List” of banned ingredients. This formula is gluten-free, soy-free, and contains no stearates.
- Riboflavin 5′-Phosphate Sodium (36.5 mg): The body-ready active form.
- Calcium Laurate: A natural, safe manufacturing aid.
- Hypromellose Capsule: Vegetarian and clean.
How to Use
Take 1 capsule one to three times daily, or as recommended by your health practitioner. For specific protocols, practitioners often titrate this specific active form differently than generic Riboflavin.
Read the clinical data regarding B2 efficacy here: NIH Study: Riboflavin (Vitamin B2) for the prevention of migraine.




















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