
If your doctor has flagged high homocysteine levels or if you have the MTHFR gene mutation, this Homocysteine Factors review explains why this is the clinical standard for vascular protection.
What is Homocysteine?
Homocysteine is a metabolic byproduct. At high levels, it damages the lining of your arteries and increases the risk of blood clots and heart issues.
The Problem: To clear it, your body needs B-Vitamins. But many people cannot absorb standard B-Vitamins due to genetics (MTHFR).
The Solution: This formula uses pre-methylated vitamins (Metafolin® and Methyl-B12) that your body can use immediately to “recycle” homocysteine into harmless amino acids.
Clinical Dosing
- Folate (as Metafolin® L-5-MTHF): The only form of folate that crosses the blood-brain barrier. Essential for DNA repair and healthy pregnancy.
- Vitamin B12 (as Methylcobalamin): Supports nerve health and works with folate to lower homocysteine.
- Vitamin B6 (as P5P): The active form required for over 100 enzymatic reactions in the body.
- Betaine (TMG): A liver-supporting nutrient that acts as a “backup” methyl donor to ensure homocysteine levels stay low.
Hypoallergenic & Pure
Pure Encapsulations is famous for what they leave out. No hidden fillers, no coatings, no binders. Just the active ingredients in a vegetarian capsule.
Take 1 capsule, 2 times daily, with meals. This supplement is frequently recommended for women during preconception and pregnancy to support healthy neural tube development (consult your OBGYN).













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